For over ten years, between 1983 and 1993, the researchers of medicinal plants, made an extensive experimental research, chemistry, pharmacology and clinical properties of guava leaves, and showed that extracts of Psidium guajava leaves have a group of novel compounds, present only in this plant, known scientifically as gammapironas, belonging to the subclass of flavonoids glycosylated.
Such a set of natural compounds present in the leaves of this tree produced in the body four complementary effects very useful for the treatment of various gastrointestinal disorders, which explains its long and ancient usage to combat diarrhea, cramps and various gastrointestinal complaints:
a) antispasmodic effect due to the antagonistic action of Ca + in the contraction of intestinal and uterine muscle fiber, which explains its usefulness in eliminating diarrhea, intestinal colic and menstrual cramps in a few minutes.
b) intestinal anti-inflammatory effect through its action on the prostaglandin cascade, which explains its usefulness in reducing gastrointestinal inflammation in acute and chronic colitis.
c) antimicrobial effect, because of its mild antibiotic properties, primarily on common pathogenic bacteria that cause alterations in peristalsis (constipation accompanied by episodes of diarrhea) or through consumption of contaminated products.
d) the antioxidant property, which explains its curative effect of intestinal irritation caused by poor eating habits (such as excessive alcohol consumption, spicy, caffeine and soft drinks) and stress, giving rise to the irritable bowel syndrome.
The discoverers have named the joint effects of extract of guava leaves as whole ownership regulatory, ie, a natural product that regulates nerve function or rearranges the digestive system and promote its use in developing phytomedicines or bush medicines for treatment of nervous colitis, irritable bowel syndrome, acute diarrhea, menstrual cramps and other ailments are extremely common, accompanied by pain and gastrointestinal inflammation, resulting in impaired function of the nervous system called enteric or intestinal.